Kutshanje, i-Desulfovibrio Vulgaris (i-Desulfovibrio Vulgaris), i-acetic acid ephezulu evelisa ibhaktheriya, ipapashwe kwi-intanethi kwijenali yamazwe ngamazwe ye-Microbiology yi-Gut Microbes (iSithili 1). Ibhaktiriya enamandla evelisa iacetic acid, ithomalalisa isifo sesibindi esinamafutha angekho butywala kwiimpuku.

Isifo sesibindi esinamafutha e-non-alcoholic (NAFLD) sisifo sesibindi esingapheliyo, kwaye okwangoku kusekho ukungabikho kwamachiza onyango olusebenzayo. Inani elikhulu lophononongo lubonise ukuba ukuphazamiseka kwe-intestinal microbiota yinto ebalulekileyo kwi-pathogenesis yezifo ze-metabolic ezisekelwe ekutyebeni. Ke ngoko, ukujolisa kulawulo lwe-intestinal microbiota kuthathwa njengesicwangciso esitsha esibalulekileyo sothintelo kunye nonyango lwezifo ze-metabolic.

Iipolysaccharides luhlobo lweekhompawundi zendalo ze-macromolecular ezisasazwa ngokubanzi kumayeza eSintu aseTshayina. Inani elikhulu lezifundo libonise ukuba i-polysaccharides yezityalo ineempembelelo ezicacileyo kulawulo lwe-metabolism, kodwa indlela echanekileyo ayicacanga ngokupheleleyo. Iqela likaHoukai Li libonise kwizifundo zangaphambili ukuba i-astragalus membranaceus polysaccharides, eyona nxalenye isebenzayo ye-astragalus membranaceus, inokuphucula ukutyeba kakhulu kunye ne-NAFLD, kwaye yabona impembelelo yokulawula ye-ASTRAgalus membranaceus polysaccharides kwi-intestinal flora kunye ne-metabolites ngokusebenzisa uhlalutyo lwe-metagenomic oludityanisiweyo kunye ne-metagenomic metabonomic. I-axis hypothesis ye "drug-intestinal microbiota - metabolite - host metabolism" yacetywayo ukuphucula ukubunjwa kwe-NAFLD yi-APS.

Ngokusekelwe kule ngcamango yesayensi, iqela lophando lihlolisise iibhaktheriya ezithile zamathumbu kunye ne-metabolites ehambelanayo elawulwa yi-APS ngokusebenzisa isicwangciso sokudibanisa i-multi-omics, kwaye yafumanisa ukuba ukuphuculwa kwe-NAFLD nge-APS ayinayo kuphela iimpawu zokuxhomekeka kweflora, kodwa kunokuphucula kakhulu amathumbu. iintsholongwane (Desulfovibrio Vulgaris). Uphononongo olongezelelweyo luqinisekisile ukuba ibhaktiriya yayingeyena nje umvelisi we-H2S wendalo, kodwa yayinamandla asebenzayo okuvelisa i-acetic acid. Ukongezwa kwangaphandle kwale bhaktheriya kuphucule kakhulu i-hepatic steatosis, uvakalelo lwe-insulin kunye nokuzuza ubunzima kwiimpuku ezondla ukutya okunamafutha aphezulu. Ngokusebenzisa uhlalutyo lwe-RNA SEQ yesibindi kunye ne-molecular biology study, kwaqinisekiswa ukuba ukuphuculwa kwe-NAFLD kwakunxulumene nokuvinjelwa kwesibindi se-FASN kunye ne-CD36 yeprotheyini yokubonakalisa. Olu pho nonongo lunikeze ubungqina obutsha bokuchaza indlela ye-APS ekuphuculeni i-NAFLD, kwaye iphinde inike ireferensi yokuhlola indlela ye-APS ekulawuleni i-intestinal flora kunye nokuphucula i-metabolism yomkhosi ngoncedo lweteknoloji ye-multiomics.

Uhlalutyo lwamacandelo e-astragalus polysaccharide monosaccharide kolu phononongo luncediswe liqela likaNjingalwazi uDing Kan ovela eShanghai Institute of Materia Medica, iChinese Academy yeSayensi, kunye nemetabolomics ekujoliswe kuyo kunye noyilo lwesifundo zixhaswe ngamandla liqela likaNjingalwazi uJia Wei kwiSibhedlele seSithandathu sabantu esidibeneyo. kwiYunivesithi yaseShanghai Jiao Tong. UNingning Zheng kunye no-Wei Jia ngababhali abahambelanayo bephepha. U-Hong Ying, umviwa ogqirha weqela likaNjingalwazi uLi Houkai, ungumbhali wokuqala wephepha, kunye neYunivesithi yaseShanghai yeTraditional Chinese Medicine ngumsayini wokuqala wephepha. Uphando lwaxhaswa ngemali yiNational Natural Science Research Foundation yaseTshayina.